Investigation of the Relationship between Headache and Anxiety during the Late COVID-19 Pandemic Period: A Prospective Case-Control Study

Objective: The effects of the COVID-19 pandemic on both physical and psychological well-being individuals have not yet been clearly understood. Especially during early period pandemic, most prevalent included fear, preoccupation with health, anxiety, feeling loneliness caused by a general sense uncertainty. incidence headache was as high 70% among mild cases. Findings from past coronavirus outbreaks indicated that neuropsychiatric symptoms might cause significant health burden adversely affect patients’ quality life. present study aimed to investigate anxiety-related clinical conditions patients diagnosed primary headache, who presented neurology polyclinic prolonged period.
 Methods: research designed two-center, prospective case-control study. Patients outpatient clinic, healthy volunteers without diagnosis were in Data collection tools sociodemographic data form, Headache Impact Test, Coronavirus Anxiety Scale Short Form, Disease Perception Scale.
 Results: collected total 869 participants, including 408 (47%) 461 (53%) volunteers, investigated. results Test-6 suggested severe effect life 187 participants (45.8%) group 73 (15.8%) Control Group (p=0.001). There anxiety 59 (14.5%) 8 (1.7%) Furthermore, rate had did 44 (13.7%) 22 (4.1%), respectively (p=0.001).
 Conclusion: revealed higher than controls those COVID-19. Further studies larger samples are necessary for investigating long term individuals.